January 30, 2019Clinical and Experimental Pharmacology and Physiology

Differences in the response to periarterial nerve stimulation or exogenous noradrenaline infusion in the mesenteric vascular bed with the intestinal tract harvested from commonly used rat models of hypertension

View Full Paper

Ask AI

Bookmark

Why the study?

Elevation in blood pressure in hypertensive rat models due to adrenergic vasoconstriction reactivity had not been well characterized in a centralized experiment.

Population

SHR, DOCA-salt, and Dahl salt-sensitive HS rat models and their respective controls

Comparison

Periarterial nerve stimulation or exogenous noradrenaline infusion vs controls across hypertensive rat models

Design

Preclinical ex vivo comparative study

Authors

SGShuji GamohKyushu University of Health and Welfare TSTatsuo ShibaKyushu University of Health and Welfare DDDonald J. DiPetteUniversity of South Carolina

Discussion

Member takes

Implication

Adrenergic reactivity may drive BP in common rat models; leaves open translation to human hypertension research.

Structured PICO

Population

Hypertensive rat models (spontaneous hypertensive rat [SHR], deoxycorticosterone acetate [DOCA]-treated and high salt intake rat [DOCA-salt], and high sodium-fed Dahl salt-sensitive rat [HS]) and their respective controls

Intervention

Periarterial nerve stimulation (PNS) or exogenous noradrenaline (NA) infusion

Comparator

Respective control rats

Outcome

Pressor responses (changes in perfusion pressure) in the isolated mesenteric vascular bed with the intestinal tractsurrogate

The reactivity of mesenteric adrenergic vasoconstriction differs significantly among commonly used experimental hypertensive rat models.

Cite This Study

Gamoh et al. (2019) studied this question.

synapsesocial.com/papers/6a796d9614b028facf0dc3dd https://doi.org/10.1111/1440-1681.13068

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Differences in the response to periarterial nerve stimulation or exogenous noradrenaline infusion in the mesenteric vascular bed with the intestinal tract harvested from commonly used rat models of hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Differences in the response to periarterial nerve stimulation or exogenous noradrenaline infusion in the mesenteric vascular bed with the intestinal tract harvested from commonly used rat models of hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider