Population
Thrombocytopenic mice lacking transcription factor p45 NF-E2 and normal littermates
Comparison
Intravenous injection of 125I-Tpo vs Normal littermates
Design
Preclinical
Authors
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Megakaryocyte Tpo sinks may modulate levels in thrombocytopenia models; leaves open human translation and clinical relevance.
The study demonstrates that megakaryocytes and platelet-like particles act as a sink for circulating thrombopoietin in NF-E2 knockout mice, explaining the absence of elevated serum Tpo levels in this model of thrombocytopenia.
Shivdasani et al. (1997) studied this question.
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