Why the study?
Nifedipine does not usually provoke cardiac failure in humans despite its negative inotropic effect, having previously caused heart failure only in the presence of fixed outflow tract obstruction.
Case Report (n=1)
No
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Reports acute pulmonary oedema triggered by nifedipine without fixed outflow tract obstruction, indicating risks of heart failure even without outflow impairment.
Nifedipine does not usually provoke cardiac failure in man' despite having a negative inotropic effect on isolated heart muscle.On the other hand, nifedipine treatment may help patients with heart failure because it reduces after-load.2 3 Nifedipine, however, brought on heart failure in a patient with fixed outflow tract obstruction4 in whom after-load could not be reduced.We report on a patient who developed pulmonary oedema after nifedipine treatment in the absence of a fixed outflow tract obstruction.
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Robson et al. (1982) conducted a case report in Angina decubitus, severe three-vessel coronary artery disease, and impaired left ventricular function (n=1). Nifedipine combined with atenolol vs. Withdrawal of nifedipine while continuing atenolol, nitrates, and diuretics was evaluated on Congestive heart failure and pulmonary oedema.
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