What question did this study set out to answer?

To characterize the physiological alterations, sodium balance, and comparative ventricular responses during chronic congestive heart failure caused by tricuspid insufficiency and pulmonic stenosis.

November 1, 1959Circulation Research

Physiologic Changes during Chronic Congestive Heart Failure in Dogs with Tricuspid Insufficiency and Pulmonic Stenosis

View Full Paper

Ask AI

Bookmark

Population

Dogs with surgically-produced tricuspid insufficiency and pulmonic stenosis

Design

Preclinical

Authors

NYNicholas A. YankopoulosUnited States Department of Veterans Affairs JDJames O. DavisUniversity of Alberta JMJames A. McFarlandPalmetto Health Richland

Discussion

Member takes

Implication

Ascites tied to right atrial pressure without LV involvement in canine models; leaves open translation to human right heart failure syndromes.

Key Points

To characterize the physiological alterations, sodium balance, and comparative ventricular responses during chronic congestive heart failure caused by tricuspid insufficiency and pulmonic stenosis.
Surgically produced tricuspid insufficiency and pulmonic stenosis in a canine model to induce chronic congestive heart failure.
Assessed intracardiac pressures, ascitic fluid accumulation, urinary sodium excretion rates, post-mortem ventricular muscle mass, and lung pathology for chronic passive congestion.
Ascites developed in association with elevated mean right atrial pressure, with animals predominantly exhibiting sodium retention alongside intermittent periods of sodium balance and natriuresis.
Marked right ventricular hypertrophy occurred in the absence of left ventricular hypertrophy, left ventricular failure, or chronic pulmonary congestion.

Structured PICO

Population

Dogs with surgically-produced tricuspid insufficiency and pulmonic stenosis

Intervention

Surgically-produced tricuspid insufficiency and pulmonic stenosis (disease model)

Outcome

Physiologic changes including ascites formation, right atrial pressure, urinary sodium excretion, intracardiac pressures, ventricular muscle mass, and lung congestionsurrogate

In a canine model of chronic congestive heart failure induced by tricuspid insufficiency and pulmonic stenosis, significant right ventricular hypertrophy and variable sodium retention occur without left ventricular involvement.

Cite This Study

Yankopoulos et al. (1959) studied this question.

synapsesocial.com/papers/6a79a7c014b028facf0de7fc https://doi.org/10.1161/01.res.7.6.950

Topics

Tricuspid regurgitation Heart failure Valvular heart disease HFrEF treatment

View Full Paper

Ask AI

Bookmark

Implication

Ascites tied to right atrial pressure without LV involvement in canine models; leaves open translation to human right heart failure syndromes.

Physiologic Changes during Chronic Congestive Heart Failure in Dogs with Tricuspid Insufficiency and Pulmonic Stenosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Physiologic Changes during Chronic Congestive Heart Failure in Dogs with Tricuspid Insufficiency and Pulmonic Stenosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider