Key result
End-stage renal disease was associated with significantly higher serum myoglobin, CK-MB levels, and mean CA-IMT compared to healthy controls (p < 0.01), whereas cTnI levels did not differ (p = 0.70).
Why the study?
Are cardiac injury markers (myoglobin, CK-MB, cTnI) elevated in ESRD patients without CAD, and do they correlate with asymptomatic atherosclerosis (CA-IMT)?
Population
52 end-stage renal disease patients without coronary artery disease and 17 healthy controls.
Design
Cross-sectional
Authors
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cTnI may remain reliable in ESRD without false elevation; leaves open its value as atherosclerosis marker pending prospective studies.
Case-Control (n=69)
Are cardiac injury markers (myoglobin, CK-MB, cTnI) elevated in ESRD patients without CAD, and do they correlate with asymptomatic atherosclerosis (CA-IMT)?
p-value: p=<0.01
In ESRD patients without CAD, cTnI levels are not falsely elevated compared to controls and correlate with carotid intima-media thickness, suggesting it may be a reliable marker for premature atherosclerosis.
Mutluay et al. (2010) conducted a case-control in End-stage renal disease (n=69). End-stage renal disease vs. Healthy controls was evaluated on Serum myoglobin, CK-MB levels, and mean CA-IMT (p=<0.01). End-stage renal disease was associated with significantly higher serum myoglobin, CK-MB levels, and mean CA-IMT compared to healthy controls (p < 0.01), whereas cTnI levels did not differ (p = 0.70).
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