Why the study?
Does acute oral captopril alter the hormonal and renal responses to head-up tilt in normal subjects?
Population
6 normal subjects on unrestricted sodium intake
Comparison
Acute oral administration of captopril 50 mg… vs Responses to tilt before captopril administration
Design
Other
Follow-up
acute
Authors
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Captopril attenuates tilt responses in normals; leaves open whether ACE inhibition alters orthostasis in patients with cardiovascular disease.
Does acute oral captopril alter the hormonal and renal responses to head-up tilt in normal subjects?
Angiotensin mediates part of the renal hemodynamic and functional responses to tilt and is the primary determinant of tilt-induced aldosterone stimulation in normal humans.
Mimran et al. (1983) studied this question.