Correlation of Pre-Hypertension with Carotid Artery Damage in Middle-Aged and Older Adults

Q: What are the key findings of this study?

Pre-hypertension was associated with increased odds of carotid artery damage compared to normotension, including maximum luminal diameter and minimum luminal diameter.

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Pre-hypertension and carotid artery damage (n=544). Intervention: Pre-hypertension (120–139/80–89 mmHg) vs. Normotensive (<120/80 mmHg). Primary outcome: Carotid artery damage (maximum luminal diameter [LDmax] ≥75th percentile in age-adjusted Model 3) (OR 2.10, p=<0.05).

Q: What does this research mean for the field?

Pre-hypertension is significantly associated with carotid artery damage, conferring increased odds of abnormal luminal diameter and altered flow velocity compared to normotension. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To investigate the association between pre-hypertension and carotid artery structural and hemodynamic damage in middle-aged and older adults.

Park jinkee; Yongseong Na; Yun-Jung Jang; Song‐Young Park; Hyuntae Park

doi:10.3390/ijerph17207686

October 21, 2020International Journal of Environmental Research and Public HealthOpen Access

Correlation of Pre-Hypertension with Carotid Artery Damage in Middle-Aged and Older Adults

View Full Paper

Ask AI

Bookmark

Share

Key result

Pre-hypertension is linked to ~2.1-fold higher odds of carotid artery damage versus normotension.

OR 2.10
P<0.05
n=544

Figures

Why the study?

Carotid artery characteristics and pre-hypertension are both independent risk factors for cardiovascular disease, prompting investigation into the association between pre-hypertension and carotid artery damage.

Is pre-hypertension associated with carotid artery damage in middle-aged and older adults?

Key Points

To investigate the association between pre-hypertension and carotid artery structural and hemodynamic damage in middle-aged and older adults.
Evaluated 544 adults classified into normotensive (n=274, 50.4%), pre-hypertensive (n=150, 27.6%), and hypertensive (n=120, 22.1%) groups.
Measured blood pressures using a mercury-free sphygmomanometer and assessed carotid artery characteristics using ultrasound imaging.
Conducted analysis of covariance (ANCOVA) and multinomial logistic regression to evaluate odds ratios (ORs) for carotid artery damage across blood pressure categories.
In unadjusted Model 2, pre-hypertension was associated with significantly higher odds of damage in IMTmax (OR 4.20), LDmax (OR 2.70), LDmin (OR 3.52), peak-systolic flow velocity (OR 2.41), end-diastolic flow velocity (OR 3.06), PFV/LDmin (OR 3.55), EFV/LDmax (OR 3.29), compliance (OR 2.02), and β-stiffness (OR 1.84) compared to normotension.
In Model 3 adjusted for age, pre-hypertension remained associated with increased odds of damage for LDmax (OR 2.10), LDmin (OR 2.55), end-diastolic flow velocity (OR 1.96), PFV/LDmin (OR 2.20), and EFV/LDmax (OR 2.04) versus normotension.
ANCOVA demonstrated significant differences among blood pressure groups across IMTmax, IMTmean, IMTmin, LDmax, LDmin, PFV, EFV, PFV/LDmin, and EFV/LDmax after multivariate adjustment (p < 0.001).

Study Design

Type

Cross-Sectional (n=544)

Multicenter

Yes

Structured PICO

Is pre-hypertension associated with carotid artery damage in middle-aged and older adults?

P

Population

544 South Korean adults aged 20-85 years (mean age 55.2 ± 18.2 years) classified as normotensive, pre-hypertensive, or hypertensive in a cross-sectional evaluation.

E

Exposure

Pre-hypertension (exposure)

C

Comparator

Normotensive

O

Outcome

Carotid artery characteristics (intima-media thickness, luminal diameters, flow velocities, compliance, and β-stiffness) measured by ultrasoundsurrogate

Main Result

Odds Ratio: 2.1

p-value: p=<0.05

Pre-hypertension is significantly associated with structural and functional carotid artery damage in middle-aged and older adults, highlighting the potential need for early cardiovascular risk management.

Limitations

Cross-sectional design
CVD-related biochemical markers such as serum lipids, glucose, and C-reactive protein were not examined
Significant age difference between pre-hypertensive and normotensive groups
Reliance on self-reported questionnaires (IPAQ) for physical activity and patient history

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

May support vascular monitoring in pre-hypertension; leaves open causal effects and need for prospective trials.

Abstract

The intima-media thickness (IMT), luminal diameters (LDs), flow velocities (FVs), compliance, and β-stiffness of the carotid artery (CA) are considered as independent risk factors for cardiovascular diseases (CVDs). Pre-hypertension (PHT) is also an independent CVD risk factor. This study investigated the association between CA damage (CAD) and PHT. A total of 544 adults participated; their blood pressures (BPs) and CA characteristics were measured using a mercury-free sphygmomanometer and ultrasound. Analysis of covariance (ANCOVA) was performed to assess the differences in the CA characteristics according to the BPs, multinomial logistic regression to evaluate the risk of CAD associated with PHT. In ANCOVA, the CA characteristics of PHT were significantly different from normotensive. The odds ratios (ORs) of IMTmax, LDmax, LDmin, peak-systolic FV (PFV), end-diastolic FV (EFV), PFV/LDmin, EFV/LDmax, compliance, and β-stiffness of PHT were 4.20, 2.70, 3.52, 2.41, 3.06, 3.55, 3.29, 2.02, and 1.84 times higher than those of the normotensive, respectively, in Model 2. In Model 3 adjusted for age, the ORs of LDmax, LDmin, EFV, PFV/LDmin, and EFV/LDmax of PHT were 2.10, 2.55, 1.96, 2.20, and 2.04 times higher than those of the normotensive, respectively. Therefore, the present study revealed that CAD is closely correlated with pre-hypertensive status in adults.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

jinkee et al. (2020) conducted a cross-sectional in Pre-hypertension and carotid artery damage (n=544). Pre-hypertension (120–139/80–89 mmHg) vs. Normotensive (<120/80 mmHg) was evaluated on Carotid artery damage (maximum luminal diameter [LDmax] ≥75th percentile in age-adjusted Model 3) (OR 2.10, p=<0.05). Pre-hypertension was associated with increased odds of carotid artery damage compared to normotension, including maximum luminal diameter and minimum luminal diameter.

synapsesocial.com/papers/6a79fe22bdf697b3de0275d7 https://doi.org/10.3390/ijerph17207686

View Full Paper

Ask AI

Bookmark

Share

Correlation of Pre-Hypertension with Carotid Artery Damage in Middle-Aged and Older Adults

Figures

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Correlation of Pre-Hypertension with Carotid Artery Damage in Middle-Aged and Older Adults

Figures

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading