Partial VP1 sequencing successfully typed 1,121 human enterovirus isolates, including 48 traditional serotypes and 8 newly discovered types that would have remained untypeable by neutralization.
Observational (n=1,121)
No
Partial VP1 sequencing is a reliable and efficient method for routine typing of human enteroviruses, capable of identifying novel types untypeable by traditional neutralization.
We have successfully typed 1,121 human enterovirus (HEV) isolates during the last 8 years by adapting partial VP1 sequencing to routine identification of HEV isolated from diverse clinical and environmental specimens. The isolates include 48 of the 59 traditional nonpoliovirus HEV serotypes and members of 8 newly discovered types, which would have remained untypeable by neutralization using the conventional cross-sectional pools of antisera.
Blomqvist et al. (2008) conducted an observational in Human enterovirus infection (n=1,121). Partial VP1 sequencing vs. Neutralization assay was evaluated on Successful typing of human enterovirus isolates. Partial VP1 sequencing successfully typed 1,121 human enterovirus isolates, including 48 traditional serotypes and 8 newly discovered types that would have remained untypeable by neutralization.