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November 1, 1992Proceedings of the National Academy of SciencesOpen Access

Translational enhancement of the poliovirus 5' noncoding region mediated by virus-encoded polypeptide 2A.

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Population

Human HeLa cells, monkey COS cells, and mouse OST7-1 cells

Comparison

Expression of poliovirus-encoded polypeptide 2A… vs Mock-infection or expression of mutant forms of 2A

Design

Preclinical

Authors

SHSimon J. HambidgeDenver Health Medical CenterPSPeter SarnowStanford University

Discussion

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Implication

Hypothesis-generating for IRES-mediated viral translation; leaves open therapeutic targeting of 2A in human infections.

Structured PICO

P
Population
Human HeLa cells, monkey COS cells, and mouse OST7-1 cells
I
Intervention
Expression of poliovirus-encoded polypeptide 2A or infection with poliovirus
C
Comparator
Mock-infection or expression of mutant forms of 2A
O
Outcome
Translation rate of mRNAs bearing the 5' noncoding region of poliovirussurrogate

Poliovirus polypeptide 2A acts as a translational transactivator for viral mRNAs containing the internal ribosome entry site, allowing efficient viral translation early in infection.

Cite This Study

Hambidge et al. (1992) studied this question.

synapsesocial.com/papers/6a7a23fefb5b6b43000debcdhttps://doi.org/10.1073/pnas.89.21.10272
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Translation in Mammalian Cells of a Gene Linked to the Poliovirus 5′ Noncoding Region1988 · 111 citations
  2. 2Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.1982 · 590 citations
  3. 3Translational Regulation of the Immunoglobulin Heavy-Chain Binding Protein mRNA2017 · 23 citations
  4. 4Cap-Independent Translation of Picornavirus RN As: Structure and Function of the Internal Ribosomal Entry Site2017 · 205 citations
  5. 5Restricted growth of attenuated poliovirus strains in cultured cells of a human neuroblastoma1989 · 83 citations