Carotid plaque-thickness and common carotid IMT show additive value in cardiovascular risk prediction and reclassification
Key result
Maximum carotid plaque thickness and mean common carotid intima-media thickness independently predicted combined vascular events (HR 1.98, 95% CI 1.47-2.67 and HR 1.68, 95% CI 1.23-2.29, respectively).
Why the study?
Does the measurement of carotid plaque thickness and common carotid IMT improve the prediction of combined vascular events in a European cohort?
Population
3,703 participants in the IMPROVE-study (European cohort)
Comparison
Top quartile of carotid plaque thickness and… vs Bottom 1-3 quartiles of cIMT max and PF CC-IMT…
Design
Cohort
Follow-up
36.2 months
Authors
Discussion
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Implication
May refine VE risk stratification with complementary carotid measures; leaves open incremental value beyond standard scores.
Study Design
Type
Cohort (n=3,703)
Multicenter
Yes
Structured PICO
Does the measurement of carotid plaque thickness and common carotid IMT improve the prediction of combined vascular events in a European cohort?
P
Population
3,703 participants in a European cohort followed for 36.2 months to evaluate the predictive value of carotid plaque thickness and intima-media thickness for vascular events.
E
Exposure
Top quartile of carotid plaque thickness (cIMT max) and plaque-free mean common carotid intima-media thickness (PF CC-IMT mean)
C
Comparator
Bottom 1-3 quartiles of cIMT max and PF CC-IMT mean
O
Outcome
Combined vascular events (coronary, cerebral, and peripheral) at 36.2-month follow-upcomposite
Main Result
Hazard Ratio: 1.98 (95% CI 1.47–2.67)
Carotid plaque thickness and common carotid IMT provide independent and additive value for cardiovascular risk prediction and reclassification beyond traditional risk factors.
Cite This Study
Amato et al. (2017) conducted a cohort in Cardiovascular risk (n=3,703). Top quartile of maximum carotid plaque thickness (cIMT max) vs. 1-3 quartiles of cIMT max was evaluated on Combined vascular events (VEs) (HR 1.98, 95% CI 1.47-2.67). Maximum carotid plaque thickness and mean common carotid intima-media thickness independently predicted combined vascular events (HR 1.98, 95% CI 1.47-2.67 and HR 1.68, 95% CI 1.23-2.29, respectively).