Why the study?
Is the ACE gene DD genotype associated with increased plasma PAI-1 levels in subjects attending routine health screening?
Population
824 subjects (603 men and 221 women) attending a routine health screening
Comparison
ACE gene DD genotype vs ACE gene DI and II genotypes
Design
Cross-sectional
Authors
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ACE DD genotype associated with higher PAI-1 in low-risk men and postmenopausal women; hypothesis-generating for fibrinolytic modulation and should not yet change practice.
Is the ACE gene DD genotype associated with increased plasma PAI-1 levels in subjects attending routine health screening?
The ACE gene DD polymorphism is associated with elevated plasma PAI-1 levels in low-risk men and postmenopausal women, suggesting a genetic link between ACE activity and the fibrinolytic pathway.
Kim et al. (1997) studied this question.
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