Why the study?
Does h-FABP measurement improve the early detection of AMI compared to hs-TnI in patients presenting to the ED with chest pain within one hour of symptom onset and negative standard troponin?
Population
n=56 patients presenting to the emergency department with chest pain within one hour from pain onset and no…
Comparison
Heart-type fatty acid binding protein measurement vs High-sensitivity troponin I (hs-TnI) measurement
Design
Case-control
Authors
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Hypothesis-generating for h-FABP plus hs-TnI in early cTn-negative chest pain; larger validation required before any clinical role.
Does h-FABP measurement improve the early detection of AMI compared to hs-TnI in patients presenting to the ED with chest pain within one hour of symptom onset and negative standard troponin?
h-FABP may offer higher sensitivity than hs-TnI for detecting AMI in very early presenters (<1 hour) with initially negative standard troponin, though it has lower overall diagnostic accuracy.
Agnello et al. (2017) studied this question.
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