Key result
Heart-type fatty acid-binding protein (H-FABP) testing on admission yielded a negative predictive value of 100% for excluding acute myocardial infarction in patients presenting with chest pain.
Why the study?
Does baseline measurement of heart-type fatty acid-binding protein (H-FABP) rapidly exclude acute myocardial infarction in patients presenting to the emergency department with chest pain?
Observational (n=67)
Does baseline measurement of heart-type fatty acid-binding protein (H-FABP) rapidly exclude acute myocardial infarction in patients presenting to the emergency department with chest pain?
H-FABP measured at baseline in ED patients with chest pain has a 100% negative predictive value, suggesting utility as an early rule-out marker for acute myocardial infarction.
May support early AMI rule-out in ED chest pain; hypothesis-generating from case-control data and needs prospective validation.
Chest pain is one of the most frequent reasons for presentation to the emergency department (ED), although the estimated prevalence of AMI (acute myocardial infarction) in the ED is about 4%. One criterion for diagnosis of AMI is the demonstration of a rise and/or fall in cardiac troponins, but time is needed for this to happen. Thus, the use of an additional 'early marker' of cardiac injury may aid to exclude AMI rapidly. The aim of the study was to evaluate the possibility of excluding AMI with the determination of heart-type fatty acid-binding protein (H-FABP) on baseline samples of patients referring to the ED for chest pain. 26 AMI patients and 41 non-AMI comparisons were included in the study. Both H-FABP and high sensitivity cardiac troponin T (hs-cTnT) were measured in baseline samples from these subjects. H-FABP had a negative predictive value of 100%, thus indicating the possibility of its usage in a rule-out strategy for AMI in ED for patients presenting with chest pain.
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Cappellini et al. (2013) conducted an observational in Chest pain / suspected acute myocardial infarction (n=67). Heart-type fatty acid-binding protein (H-FABP) testing vs. High sensitivity cardiac troponin T (hs-cTnT) was evaluated on Negative predictive value for excluding acute myocardial infarction. Heart-type fatty acid-binding protein (H-FABP) testing on admission yielded a negative predictive value of 100% for excluding acute myocardial infarction in patients presenting with chest pain.
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