What question did this study set out to answer?

To determine the clinicopathologic features and underlying pathogenesis of painful alcoholic polyneuropathy in patients with normal thiamine status compared to beriberi neuropathy.

June 26, 2001Neurology

Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status

View Full Paper

Ask AI

Bookmark

To determine the clinicopathologic features and underlying pathogenesis of painful alcoholic polyneuropathy in patients with normal thiamine status compared to beriberi neuropathy.
Assessed clinical, electrophysiologic, and histopathologic parameters in 18 patients with painful alcoholic polyneuropathy and verified normal thiamine status.
Patients presented with a symmetric, sensory-dominant axonal polyneuropathy predominantly involving the lower limbs, marked by burning pain that progressed gradually over months to years.
Histopathologic analysis showed that densities of small myelinated and unmyelinated nerve fibers were severely reduced compared to large myelinated fibers.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Observational study uncovers predominant small-fiber axonal damage and pain in patients with chronic alcoholism and normal thiamine levels, indicating direct alcohol neurotoxicity.

Cite This Study

Koike et al. (2001) studied this question.

synapsesocial.com/papers/6a7ad77377336a1bae02fe5a https://doi.org/10.1212/wnl.56.12.1727

View Full Paper

Ask AI

Bookmark

Implication

Observational study uncovers predominant small-fiber axonal damage and pain in patients with chronic alcoholism and normal thiamine levels, indicating direct alcohol neurotoxicity.

Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status

Key Points

Discussion

Implication

Cite This Study

Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider