Key result
Adding acetylsalicylic acid to enoxaparin during in vitro haemodialysis significantly prolonged the time to circuit clotting from 120 minutes to >180 minutes (P=0.047).
Why the study?
Does adding acetylsalicylic acid to enoxaparin prolong time to filter clotting in an in vitro haemodialysis model?
Population
Blood from 42 healthy volunteers, between 18 and 60 years of age, evaluated in an in vitro haemodialysis model
Comparison
Acetylsalicylic acid 100 mg added to enoxaparin vs Enoxaparin alone (1, 1.5 or 2 mg)
Design
Preclinical
Follow-up
4 hours
Authors
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Adding aspirin to enoxaparin may reduce in vitro HD circuit clotting; leaves open clinical efficacy and safety.
Does adding acetylsalicylic acid to enoxaparin prolong time to filter clotting in an in vitro haemodialysis model?
Absolute Event Rate: 180% vs 120%
p-value: p=0.047
Adding acetylsalicylic acid to enoxaparin in an in vitro haemodialysis model prolonged time to circuit clotting and reduced transmembrane pressure.
Samaha et al. (2018) studied Healthy volunteers (in vitro haemodialysis model) (n=42). Acetylsalicylic acid vs. Standard anticoagulation (enoxaparin alone) was evaluated on time to filter clotting (p=0.047). Adding acetylsalicylic acid to enoxaparin during in vitro haemodialysis significantly prolonged the time to circuit clotting from 120 minutes to >180 minutes (P=0.047).
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