Why the study?
Does intravenous immune globulin or steroid therapy improve outcomes in children with acute myocarditis?
Population
41 children with biopsy-proven myocarditis or cardiac dysfunction and proof of concomitant cardiotropic…
Comparison
Intravenous immune globulin alone or in… vs Steroids alone or no immunomodulatory therapy
Design
Cohort
Follow-up
Up to 5 years
Authors
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No difference in death or transplant-free survival by treatment; leaves open immunomodulatory benefit in pediatric myocarditis and supports randomized trials.
Does intravenous immune globulin or steroid therapy improve outcomes in children with acute myocarditis?
In a retrospective cohort of children with acute myocarditis, treatment with IVIG or steroids did not appear to confer an advantage over supportive care alone, highlighting the need for randomized trials.
English et al. (2004) studied this question.
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