Why the study?
Does adequate antihypertensive therapy prevent stroke in stroke-prone spontaneously hypertensive rats?
Population
Stroke-prone spontaneously hypertensive rats developed by selective breeding
Design
Preclinical
Authors
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Does not support changes in clinical practice; extends preclinical evidence on early BP control in hypertensive models.
Does adequate antihypertensive therapy prevent stroke in stroke-prone spontaneously hypertensive rats?
In a selectively bred rat model, severe hypertension drives stroke incidence through local vascular changes, and early antihypertensive therapy effectively prevents strokes.
Okamoto et al. (1974) studied this question.
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