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June 1, 1995Journal of VirologyOpen Access

Cytopathogenicity of classical swine fever virus caused by defective interfering particles

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Population

Three independent cytopathogenic isolates of classical swine fever virus in infected cells

Design

Preclinical

Authors

GMGregor MeyersHTHeinz‐Jürgen Thiel

Discussion

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Overview

Suggests DI particles drive CSFV cytopathogenicity; hypothesis-generating for pathogenesis and intervention studies.

Structured PICO

P
Population
Three independent cytopathogenic isolates of classical swine fever virus in infected cells
I
Intervention
Defective interfering (DI) particles / defective RNAs
O
Outcome
Cytopathic effect and viral replication interferencesurrogate

Defective interfering particles with specific internal deletions are responsible for the cytopathic effect in classical swine fever virus isolates.

Cite This Study

Meyers et al. (1995) studied this question.

synapsesocial.com/papers/6a7c00461f8f1eb7b8ed4e35https://doi.org/10.1128/jvi.69.6.3683-3689.1995
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