Coronary microcirculatory vasodilator function in relation to risk factors among patients without obstructive coronary disease and low to intermediate Framingham score
Key result
A higher Framingham risk score was an independent predictor of reduced coronary flow reserve in patients without obstructive coronary disease (P < 0.001).
Why the study?
Does a higher Framingham risk score predict reduced coronary microcirculatory vasodilator function in patients without obstructive coronary disease?
Population
1063 patients without significant narrowing on coronary angiography who underwent invasive assessment of…
Design
Cross-sectional
Authors
Discussion
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Implication
Should not yet change practice in non-obstructive CAD; leaves open whether Framingham score refines microvascular risk stratification.
Study Design
Type
Observational (n=1,063)
Structured PICO
Does a higher Framingham risk score predict reduced coronary microcirculatory vasodilator function in patients without obstructive coronary disease?
P
Population
1,063 patients (mean age 50, 64% female) without obstructive coronary disease who underwent invasive assessment of coronary endothelial function.
O
Outcome
Coronary blood flow (CBF) in response to acetylcholine and microvascular coronary flow reserve (CFR) in response to intracoronary adenosinesurrogate
Main Result
p-value: p=<0.001
A higher Framingham risk score independently predicts reduced coronary flow reserve in patients without obstructive coronary disease, indicating microvascular dysfunction even at low-to-intermediate risk.
Cite This Study
Rubinshtein et al. (2009) conducted an observational in patients without obstructive coronary disease (n=1,063). Framingham risk score (FRS) was evaluated on reduced coronary flow reserve (CFR) (p=<0.001). A higher Framingham risk score was an independent predictor of reduced coronary flow reserve in patients without obstructive coronary disease (P < 0.001).