Why the study?
Does pindolol alter renal function in hypertensive patients with normal and decreased glomerular filtration?
Does pindolol alter renal function in hypertensive patients with normal and decreased glomerular filtration?
Long-term pindolol therapy appears safe for renal function in hypertensive patients and may improve renal blood flow in those with pre-existing renal impairment.
Supports long-term pindolol renal safety in hypertension; leaves open acute GFR effects and benefits in impaired function.
1 In an acute study in hypertensive patients with normal and decreased renal function the i.v. administration of pindolol (0.1 mg/kg) caused a decrease in inulin clearance and a concomitant but not significant decrease in PAH clearance with a constant filtration fraction. 2 The long-term administration of pindolol (5--20 mg/day) to hypertensive patients with normal renal function was not associated with changes in renal function but in patients with a decreased renal function, pindolol caused an increase in PAH clearance but no change in inulin clearance.
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Rosenfeld et al. (1982) studied this question.
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