What question did this study set out to answer?

To evaluate the effects of pindolol on renal hemodynamics, fluid compartment volumes, and endocrine regulators in patients with hypertension.

May 1, 1981Journal of Cardiovascular Pharmacology

Renal Function, Body Fluid Volumes, Renin, Aldosterone, and Noradrenaline During Treatment of Hypertension with Pindolol

View Full Paper

Ask AI

Bookmark

Why the study?

Does pindolol lower blood pressure and alter renal function, body fluid volumes, and hormone levels in hypertensive patients?

Key Points

To evaluate the effects of pindolol on renal hemodynamics, fluid compartment volumes, and endocrine regulators in patients with hypertension.
Conducted a placebo-controlled, single-blind crossover study in 16 hypertensive patients treated with pindolol (10–45 mg/day, mean ± SD: 28.75 ± 15.22 mg/day) for 3–8 weeks.
Estimated effective renal plasma flow and glomerular filtration rate using Hippuran and EDTA clearances under oral water loading.
Measured blood volume via 125I-human serum albumin, total body water via tritium dilution, and tracked plasma noradrenaline, renin activity, aldosterone, and calcium.
Pindolol significantly lowered supine and standing blood pressures without producing consistent changes in renal plasma flow or glomerular filtration rate.
Intravascular blood volume increased alongside decreased serum albumin without alterations in body weight or total body water, indicating fluid transfer from interstitial spaces.
Plasma noradrenaline, renin activity, aldosterone, and serum calcium levels decreased, with calcium changes exhibiting a strong positive correlation with blood pressure reduction.

Structured PICO

Does pindolol lower blood pressure and alter renal function, body fluid volumes, and hormone levels in hypertensive patients?

Population

16 hypertensive patients

Intervention

Pindolol (10-45 mg/day; mean 28.75 +/- 15.22 mg/day) for 3-8 weeks

Comparator

Placebo (crossover design)

Outcome

Supine and standing blood pressures, effective renal plasma flow, glomerular filtration rates, blood volume, and hormone levels (noradrenaline, renin activity, aldosterone)surrogate

Pindolol effectively lowers blood pressure in hypertensive patients while increasing intravascular volume and reducing renin-angiotensin-aldosterone system activity and sympathetic tone.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support pindolol for BP control without renal compromise; leaves open volume effects for larger trials.

Cite This Study

Wilcox et al. (1981) studied this question.

synapsesocial.com/papers/6ab6383dbb3fdd31b74492ce https://doi.org/10.1097/00005344-198105000-00018

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Renal Function, Body Fluid Volumes, Renin, Aldosterone, and Noradrenaline During Treatment of Hypertension with Pindolol

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Renal Function, Body Fluid Volumes, Renin, Aldosterone, and Noradrenaline During Treatment of Hypertension with Pindolol

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider