Key result
Mean plasma fibrinogen levels were significantly higher in patients with myocardial infarction (674.5 mg/dl) compared to healthy controls (304 mg/dl, p=0.000).
Why the study?
Fibrinogen is a major independent risk factor for cardiovascular diseases, but fibrinogen levels needed to be determined specifically in Sudanese patients with myocardial infarction.
Are fibrinogen levels significantly elevated in Sudanese patients with myocardial infarction compared to healthy controls?
Case-Control (n=100)
Yes
Are fibrinogen levels significantly elevated in Sudanese patients with myocardial infarction compared to healthy controls?
Plasma fibrinogen levels are significantly elevated in patients with myocardial infarction and correlate positively with Troponin-1 levels, supporting its association with myocardial injury.
Elevated fibrinogen was associated with MI; hypothesis-generating for causality and risk stratification, prospective studies needed.
Fibrinogen has been identified as a major independent risk factor for cardiovascular diseases. Myocardial infarction is cardiomyocyte death as result of a prolonged ischemia. The aim of this study was to determine fibrinogen level in Sudanese patients with myocardial infarction. A case control study was conducted in AL-Shaab Hospital and Sudan heart center at Khartoum state, Sudan. A total of 100 study participants were enrolled in the study; 50 were myocardial infarction patients and 50 were apparently healthy individuals as control. The blood Samples were collected in 3.2 % trisodium citrate and Fibrinogen level was measured using ready kits principle. The data were analysed by statistical package of social sciences version 21. The study revealed that fibrinogen level was higher in Myocardial infarction (MI) patients compared with normal individuals. There is a significant strong positive correlation between fibrinogen and Troponin-1 Level at the 0.05 level.
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Fadul et al. (2021) conducted a case-control in Myocardial infarction (n=100). Myocardial infarction vs. Apparently healthy individuals was evaluated on Mean fibrinogen level (mg/dl) (p=0.000). Mean plasma fibrinogen levels were significantly higher in patients with myocardial infarction (674.5 mg/dl) compared to healthy controls (304 mg/dl, p=0.000).
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