What is the clinical evidence from this study?

Study design: Systematic Review. Population: Chronic heart failure. Intervention: Serum homocysteine levels vs. Healthy controls. Primary outcome: Correlation between serum homocysteine levels and chronic heart failure.

February 5, 2021MedicineOpen Access

The association between levels of serum homocysteine and chronic heart failure

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Key result

This paper is a protocol for a systematic review and meta-analysis to evaluate the correlation between serum homocysteine levels and chronic heart failure, and thus reports no clinical results.

Why the study?

Serum homocysteine levels are elevated in chronic heart failure and suspected to be a risk factor, but evidence-based medicine evidence is lacking.

Are serum homocysteine levels associated with chronic heart failure?

Population

CHF patients and non-CHF patients across included case-control studies

Comparison

Serum Hcy levels in CHF patients vs non-CHF patients

Design

Systematic review of case-control studies

Authors

XWXi WangShandong University of Traditional Chinese Medicine FWFu WangCapital Medical University ZFZhiquan FengUniversity of Jinan

Discussion

Member takes

Implication

This protocol outlines a planned systematic review and meta-analysis to evaluate the correlation between serum homocysteine levels and chronic heart failure.

Study Design

Type

Systematic Review

Structured PICO

Are serum homocysteine levels associated with chronic heart failure?

Population

Protocol for a systematic review and meta-analysis of case-control studies evaluating the correlation between serum homocysteine levels and chronic heart failure.

Exposure

Serum homocysteine (Hcy) levels

Comparator

Healthy controls (non-CHF patients)

Outcome

Correlation between serum Hcy levels and CHFsurrogate

This protocol outlines a planned systematic review and meta-analysis to evaluate the correlation between serum homocysteine levels and chronic heart failure.

Limitations

Anticipated few included articles and small sample size
Only case-control studies will be included, meaning implementation and measurement bias cannot be avoided
Time relationship between the increase of serum Hcy levels and the occurrence and development of CHF cannot be determined
Literature search limited to English and Chinese languages, potentially ignoring studies in other languages
few included articles and small sample size
only case-control studies were included, implementation and measurement bias could not be avoided
time relationship between the increase of serum Hcy levels and the occurrence and development of CHF could not be determined
only search the English and Chinese literatures

Cite This Study

Wang et al. (2021) conducted a systematic review in Chronic heart failure. Serum homocysteine levels vs. Healthy controls was evaluated on Correlation between serum homocysteine levels and chronic heart failure. This paper is a protocol for a systematic review and meta-analysis to evaluate the correlation between serum homocysteine levels and chronic heart failure, and thus reports no clinical results.

synapsesocial.com/papers/6a7ca2ee5de18cf3f8fab212 https://doi.org/10.1097/md.0000000000024117

Topics

Heart failure HFrEF treatment

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Implication

This protocol outlines a planned systematic review and meta-analysis to evaluate the correlation between serum homocysteine levels and chronic heart failure.

The association between levels of serum homocysteine and chronic heart failure

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Topics

The association between levels of serum homocysteine and chronic heart failure

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider