Why the study?
Does Salicornia bigelovii Torr. plant salt prevent hypertension compared to edible salt in SD rats?
Does Salicornia bigelovii Torr. plant salt prevent hypertension compared to edible salt in SD rats?
Salicornia bigelovii Torr. plant salt may serve as a salt substitute that avoids hypertension and protects kidney and liver function through antioxidant mechanisms in a rat model.
May support SPS testing as salt substitute in models; leaves open human translation and requires clinical trials.
In this paper, the effect and mechanism of Salicornia bigelovii Torr. plant salt (SPS) on blood pressure in Sprague Dawley (SD) rats were investigated. The results showed that the edible salt induced hypertension, but the SPS did not. Organ indices and Hematoxylin-Eosin (HE) staining analysis indicated that SPS had a protective effect on the kidney and liver. In comparison with the edible salt-treated group, nitric oxide (NO) content, angiotensin-II (Ang-II) and endothelin-1 (ET-1) levels in the serum of the SPS-treated group had no obvious changes, but serum creatinine concentration significantly decreased. Moreover, superoxide dismutase (SOD) and Na(+)-K(+)-ATPase activity increased while malondialdehyde (MDA) content decreased in the SPS-treated group. In conclusion, a long-term high salt intake could lead to hypertension. SPS, as a salt substitute, could increase the body's antioxidant ability to protect the kidney and liver from the damage caused by a high salt intake and effectively avoid the occurrence of hypertension.
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Zhang et al. (2015) studied this question.
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