Why the study?
Does fentanyl at 50 μg.kg-1 reduce the cortisol and hyperglycemic response to upper abdominal surgery compared to 10 or 30 μg.kg-1?
Does fentanyl at 50 μg.kg-1 reduce the cortisol and hyperglycemic response to upper abdominal surgery compared to 10 or 30 μg.kg-1?
High-dose fentanyl (50 μg/kg) effectively suppresses the cortisol stress response during upper abdominal surgery, though it does not prevent hyperglycemia.
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High-dose fentanyl suppresses cortisol but not hyperglycemic response to upper abdominal surgery; confirms selective opioid attenuation of endocrine surgical stress.
Plasma cortisol and glucose were measured during upper abdominal surgery in 25 patients randomly allocated to groups receiving fentanyl doses of 10, 30 or 50 μg.kg ‐1 . The results showed that fentanyl 50 μg.kg ‐1 abolished the cortisol response to surgery observed in patients receiving 10 or 30 μg.kg ‐1 . In contrast, the hyperglycemic response was uninfluenced by fentanyl at any dose.
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Haxholdt et al. (1981) studied this question.
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