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November 6, 2019JAMA CardiologyOpen Access

Association of Obesity With Adverse Long-term Outcomes in Hypertrophic Cardiomyopathy

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Why the study?

Patients with hypertrophic cardiomyopathy are prone to body weight increase and obesity, but whether this predisposes them to long-term adverse outcomes remains unresolved.

Does obesity increase the risk of adverse long-term outcomes in patients with hypertrophic cardiomyopathy?

Population

3282 patients with HCM from an international multicenter registry

Comparison

Obesity (>30) vs preobesity (25-30) vs normal weight (<25) BMI groups

Design

Retrospective cohort study

Follow-up

Median 6.8 years

Authors

CFCarlo FumagalliNMNiccolò MauriziSDSharlene M. Day

Discussion

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Overview

Higher BMI may associate with worse HCM outcomes; hypothesis-generating and should not yet change practice.

Structured PICO

Does obesity increase the risk of adverse long-term outcomes in patients with hypertrophic cardiomyopathy?

P
Population
3,282 patients with hypertrophic cardiomyopathy (HCM) with 1 or more follow-up visits, mean age at diagnosis 47 years, 61.5% male, from the international Sarcomeric Human Cardiomyopathy Registry (8 high-volume centers).
I
Intervention
Obesity (BMI >30) and preobesity (BMI 25-30)
C
Comparator
Normal weight (BMI <25)
O
Outcome
Overall composite outcome (first occurrence of any component of the ventricular arrhythmic or heart failure composite end point, all-cause mortality, atrial fibrillation, or stroke)composite

In patients with hypertrophic cardiomyopathy, obesity is independently associated with a significantly higher risk of heart failure and overall adverse composite outcomes.

Cite This Study

Fumagalli et al. (2019) studied this question.

synapsesocial.com/papers/6a7cdd7edfdd4c7a333aa73ehttps://doi.org/10.1001/jamacardio.2019.4268
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypertrophic Cardiomyopathy Is Predominantly a Disease of Left Ventricular Outflow Tract Obstruction2006 · 1,129 citations
  2. 2Physical activity in hypertrophic cardiomyopathy: prevalence of inactivity and perceived barriers2016 · 82 citations
  3. 3Effect of Left Ventricular Outflow Tract Obstruction on Clinical Outcome in Hypertrophic Cardiomyopathy2003 · 1,473 citations
  4. 4Functional Status, Pulmonary Artery Pressure, and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction2016 · 108 citations
  5. 5Obesity and the Risk of New-Onset Atrial Fibrillation2004 · 1,415 citations