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September 1, 1996ASAIO Journal

Isolation of “Myocardial Depressant Factor(s)” From the Ultrafiltrate of Heart Failure Patients With Acute Renal Failure

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Population

Hemofiltrate samples from 20 patients: 4 with acute congestive heart failure and acute renal failure, 8 with…

Comparison

Injection of fractionated hemofiltrate samples vs Vehicle and preparatory elements

Design

Preclinical

Authors

PBP H BlakeYHYuko HasegawaMKM. C. Khosla

Discussion

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Overview

Indicates circulating myocardial depressants in HF with renal failure; hypothesis-generating for clinical relevance and human therapies.

Structured PICO

P
Population
Hemofiltrate samples from 20 patients: 4 with acute congestive heart failure and acute renal failure (Group I), 8 with chronic congestive heart failure and mild renal failure (Group II), and 8 with end-stage renal disease and no congestive heart failure (Group III), tested on a Langendorff rat heart preparation.
I
Intervention
Injection of fractionated hemofiltrate samples (eluted with methanol/water mixtures and fractionated by HPLC)
C
Comparator
Vehicle and preparatory elements (0.1 M HCl, 0.08 M acetic acid, Na acetate, 0.1 M NaHCO3, Na citrate, and Na glutarate)
O
Outcome
Inotropic response (myocardial depression)surrogate

Hemofiltrate from patients with heart failure and renal failure contains factors that exert a direct myocardial depressant effect in an isolated rat heart model.

Cite This Study

Blake et al. (1996) studied this question.

synapsesocial.com/papers/6a7cebe7b1c7e2c2a8cd8ce2https://doi.org/10.1097/00002480-199609000-00127
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical significance of renal hemodynamics in severe congestive heart failure: Responsiveness to ultrafiltration therapies.1989 · 11 citations
  2. 2Clinical Efficacy of Blood Ultrafiltration Therapy in Patients with Acute Decompensated Chronic Heart Failure2023 · 1 citations
  3. 3July 2018 at a Glance: Practical Guidance in Acute Heart Failure, Pathophysiology and Clinical Trials of Medical Therapy2018
  4. 4Ultrafiltration versus Diuretics on Prognostic Cardiac and Renal Biomarkers in Acute Decompensated Heart Failure: A Systematic Review and Meta-Analysis2023 · 4 citations
  5. 5Neuroendocrine response in acute heart failure and the influence of treatment1989 · 51 citations