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January 1, 2023Physiological ResearchOpen Access

Clinical Efficacy of Blood Ultrafiltration Therapy in Patients with Acute Decompensated Chronic Heart Failure

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Why the study?

Does blood ultrafiltration therapy improve overall response rate and cardiac/renal function in patients with acute decompensated chronic heart failure?

Population

78 patients with acute decompensated chronic heart failure

Comparison

FQ-16 heart failure ultrafiltration therapy vs stepped drug therapy

Design

Randomized controlled trial

Authors

YHY-W HeFWF-Q WangFZF-F Zhang

Discussion

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Overview

Supports ultrafiltration over stepped therapy in acute decompensated chronic HF; extends RCT evidence on response rates and cardiac/renal outcomes.

Structured PICO

Does blood ultrafiltration therapy improve overall response rate and cardiac/renal function in patients with acute decompensated chronic heart failure?

P
Population
78 patients with acute decompensated chronic heart failure
I
Intervention
Blood ultrafiltration therapy using the FQ-16 heart failure ultrafiltration dehydrating device administered for 8-16 hours
C
Comparator
Stepped drug therapy
O
Outcome
Overall response ratesurrogate

Blood ultrafiltration therapy significantly improves overall response rate, cardiac function, and renal biomarkers compared to stepped drug therapy in patients with acute decompensated chronic heart failure.

Cite This Study

He et al. (2023) studied this question.

synapsesocial.com/papers/6a8156af26f0d7dff79cd37bhttps://doi.org/10.33549/physiolres.935073
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Safety and efficacy of ultrafiltration on heart failure patients with reduced ejection fraction and diuretic resistance: results from a single-center randomized controlled trial].2021 · 6 citations
  2. 2Ultrafiltration for acute heart failure2020 · 7 citations
  3. 3Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure2021 · 218 citations
  4. 4NT‐proBNP Qualifies as a Surrogate for Clinical End Points in Heart Failure2021 · 46 citations
  5. 52020 Expert Consensus on the Prevention and Treatment of Heart Failure after Myocardial Infarction2021 · 16 citations