Key result
Ultrafiltration is linked to ~300% higher mortality and cardiac arrest versus IV diuretics despite similar decongestion.
Why the study?
Studies comparing ultrafiltration and diuretics in the management of ADHF have shown controversial results.
Does ultrafiltration improve decongestion and clinical outcomes compared to intravenous diuretic therapy in patients hospitalized for acute decompensated biventricular heart failure?
Population
30 patients with ADHF and right ventricular dysfunction superimposed on left ventricular systolic dysfunction
Comparison
Ultrafiltration vs intravenous diuretic therapy
Follow-up
3 months
Authors
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Ultrafiltration should not supplant diuretics in acute biventricular HF decongestion; leaves open whether harm is causal pending randomized trials.
Cohort (n=30)
Does ultrafiltration improve decongestion and clinical outcomes compared to intravenous diuretic therapy in patients hospitalized for acute decompensated biventricular heart failure?
In patients with acute decompensated biventricular heart failure, ultrafiltration did not improve decongestion compared to intravenous diuretics and was associated with numerically higher rates of severe adverse events, though statistical power was lacking.
Şeker et al. (2016) conducted a cohort in Acute decompensated biventricular heart failure (n=30). Ultrafiltration vs. Intravenous diuretic therapy was evaluated on Weight loss, total fluid loss, and changes in serum creatinine at discharge. Ultrafiltration compared to intravenous diuretics in acute decompensated biventricular heart failure showed similar decongestion but higher rates of cardiac arrest and death (40% vs 10%).
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