Increased levels of a high calcium-requiring protease are associated with the development of cardiac lesions in myopathic hamsters, suggesting a potential role in the pathogenesis of cardiomyopathy.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for protease role in cardiomyopathy models; leaves open human relevance and should not change practice.
A high calcium-requiring protease was purified from the hearts of myopathic hamsters. The biochemical properties of the enzyme were studied with [3H]acetylcasein as substrate. Comparison of the enzyme from hamster and rat hearts indicated no species specificity. Increased levels of the enzyme were associated with the development of cardiac lesions in myopathic hamsters.
No takes yet. Share an insight, caveat, or question.
Spalla et al. (1987) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: