September 25, 2008Stem Cells

1,4,5-Inositol Trisphosphate-Operated Intracellular Ca2+ Stores and Angiotensin-II/Endothelin-1 Signaling Pathway Are Functional in Human Embryonic Stem Cell-Derived Cardiomyocytes

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Population

human embryonic stem cell-derived cardiomyocytes (hESC-CM)

Design

Preclinical

Authors

Discussion

hESC-CM may model Gq/IP3 Ca2+ signaling; hypothesis-generating and leaves open translation to adult human myocardium or therapy.

Population

human embryonic stem cell-derived cardiomyocytes (hESC-CM)

Intervention

Angiotensin-II (AT-II) and endothelin-1 (ET-1) (10^-9 to 10^-7 M)

Outcome

[Ca2+]i transients and contractions (amplitude and maximal rates of contraction and relaxation)surrogate

Human embryonic stem cell-derived cardiomyocytes exhibit functional AT-II and ET-1 signaling pathways and 1,4,5-IP3-operated releasable Ca2+ stores.

Sedan et al. (2008) studied this question.

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