June 20, 2000Proceedings of the National Academy of SciencesOpen Access

Interference fine structure and sarcomere length dependence of the axial x-ray pattern from active single muscle fibers

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Population

Single intact fibers of frog skeletal muscle

Comparison

Isometric contraction at sarcomere lengths… vs Resting fibers

Design

Preclinical

Authors

MLMarco LinariUniversity of Florence GPGabriella PiazzesiUniversity of Florence IDIan M. DobbieMicron (United States)

Discussion

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Implication

X-ray interferometry probes myosin dynamics in muscle; leaves open translation to human cardiac physiology.

Structured PICO

Population

Single intact fibers of frog skeletal muscle

Intervention

Isometric contraction at sarcomere lengths 2.2-3.2 microm

Comparator

Resting fibers

Outcome

Axial x-ray diffraction patterns (M3 x-ray reflection)surrogate

The study establishes x-ray interferometry as a high-resolution tool for studying myosin head motions, demonstrating that muscle activation alters myosin filament structure in both overlap and nonoverlap regions.

Cite This Study

Linari et al. (2000) studied this question.

synapsesocial.com/papers/6a7d4f6eb0b0e582d537dc68 https://doi.org/10.1073/pnas.97.13.7226

View Full Paper

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Interference fine structure and sarcomere length dependence of the axial x-ray pattern from active single muscle fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interference fine structure and sarcomere length dependence of the axial x-ray pattern from active single muscle fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider