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January 1, 1995Journal of Hypertension

Polymorphisms within the atrial natriuretic peptide gene in essential hypertension

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Why the study?

Are polymorphisms in the atrial natriuretic peptide gene associated with essential hypertension in African Americans?

Population

104 African Americans (60 with essential hypertension, 44 normotensive)

Design

Case-control

Authors

DRDavid R. RutledgeUniversity of Tennessee Health Science CenterYSYanmei SunGuangzhou University of Chinese MedicineEREdward A. RossUniversity of Illinois Urbana-Champaign

Discussion

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Overview

Supports ANP polymorphism association with hypertension in African Americans; leaves open replication and mechanistic studies before clinical translation.

Structured PICO

Are polymorphisms in the atrial natriuretic peptide gene associated with essential hypertension in African Americans?

P
Population
104 African Americans (60 with essential hypertension, 44 normotensive)
O
Outcome
Allele frequency of polymorphisms in the atrial natriuretic peptide gene at intron two (Hpall) and exon three (Scal)

The Hpall mutation in the atrial natriuretic peptide gene is significantly associated with essential hypertension in African Americans.

Cite This Study

Rutledge et al. (1995) studied this question.

synapsesocial.com/papers/6a7d51baf1daba58ecd5b4fchttps://doi.org/10.1097/00004872-199509000-00003

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic analysis of the atrial natriuretic peptide gene in essential hypertension2000 · 57 citations
  2. 2Genetic analysis of the atrial natriuretic peptide gene in essential hypertension2000 · 18 citations
  3. 3Association Study between the Variants of the Human ANP Gene and Essential Hypertension.2001 · 28 citations
  4. 4Molecular variants of the sodium/hydrogen exchanger type 3 gene and essential hypertension2004 · 23 citations
  5. 5A HAPLOTYPE OF THE ANGIOTENSINOGEN GENE IS ASSOCIATED WITH HYPERTENSION IN AFRICAN AMERICANS2005 · 30 citations