Why the study?
Does L-NA superfusion inhibit rCBF augmentation during vibrissal stimulation in eNOS mutant and wild type mice?
Population
Type III nitric oxide synthase (eNOS) mutant and wild type mice
Comparison
Mechanical whisker stimulation before and after… vs Wild type mice vs eNOS mutant mice; before vs…
Design
Preclinical
Authors
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Suggests nNOS primacy in murine neurovascular coupling; leaves open translation to human physiology or clinical relevance.
Does L-NA superfusion inhibit rCBF augmentation during vibrissal stimulation in eNOS mutant and wild type mice?
Coupling of blood flow and metabolism during whisker stimulation in mice appears to be dependent on neuronal NOS (nNOS) rather than endothelial NOS (eNOS).
Ayata et al. (1996) studied this question.
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