Why the study?
Does diarrhea increase oral poliovirus vaccine failure in infants?
Population
728 infants in Brazil immunized at birth and approximately 6, 10, and 14 weeks
Comparison
Oral poliovirus vaccine administration in the… vs Oral poliovirus vaccine administration without…
Design
Cohort
Follow-up
up to approximately 14 weeks
Authors
Loading...
Diarrhea around OPV dosing was associated with higher failure risk; leaves open optimal re-dosing strategies for eradication programs.
Does diarrhea increase oral poliovirus vaccine failure in infants?
Diarrhea at or recently before OPV administration increases the risk of vaccine failure, supporting recommendations to reimmunize children once their illness resolves.
Posey et al. (1997) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: