Why the study?
Does a low dose (5 mg) of sublingual nifedipine induce myocardial ischaemia in elderly hypertensive patients?
Population
n=93 consecutive hypertensive patients, 65 years of age or older, without coronary artery disease.
Comparison
Sublingual nifedipine 5 mg single dose vs Baseline (pre-administration)
Design
Cohort
Follow-up
45-60 min
Authors
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May induce myocardial ischaemia in LVH; leaves open whether low-dose sublingual nifedipine warrants caution in elderly hypertensives.
Does a low dose (5 mg) of sublingual nifedipine induce myocardial ischaemia in elderly hypertensive patients?
Even a low dose (5 mg) of sublingual nifedipine can induce myocardial ischaemia in elderly hypertensive patients, particularly those with left ventricular hypertrophy, due to a marked reduction in coronary perfusion pressure.
Ishibashi et al. (1999) studied this question.
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