Key result
Sublingual 10-mg nifedipine produced mild to moderate EKG changes and failed to achieve optimal blood pressure reduction at 30 minutes in patients with urgency hypertensive crisis.
Why the study?
Does sublingual nifedipine 10 mg improve blood pressure and cause EKG changes in patients with urgency hypertensive crisis?
Observational (n=23)
Does sublingual nifedipine 10 mg improve blood pressure and cause EKG changes in patients with urgency hypertensive crisis?
Sublingual nifedipine is ineffective for optimal blood pressure control in urgency hypertensive crisis and is associated with mild to moderate EKG changes.
Supports caution with sublingual nifedipine in hypertensive urgency; this case report leaves open need for prospective trials.
of all hypertensive patients suffer from hypertensive crisis (HC). Although not the treatment of choice, in some Latin American countries is still common the use of sublingual nifedipine in the emergency room. In this study we will compare the electrocardiographic (EKG) and arterial blood pressure changes after 30 minutes of using sublingual nifedipine. Results: We included 23 patients without cardiac disease, with urgency HC and treated with 10-mg nifedipine sublingually. Most of the patients had mild to moderate changes in the EKG, such as changes in heart rate and nonspecific ST segment deviations. One patient had symmetric inverted T waves in leads V5 and V6. PR and QT intervals with no changes. The BP after 30 minutes was not the ideal. Conclusion: Sublingual nifedipine does not absorb well and does produce changes in the EKG. Patients did not achieve an optimal BP after the administration of sublingual nifedipin.
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A 2009 study conducted an observational in Hypertensive crisis (n=23). Sublingual nifedipine was evaluated on Electrocardiographic (EKG) and arterial blood pressure changes. Sublingual 10-mg nifedipine produced mild to moderate EKG changes and failed to achieve optimal blood pressure reduction at 30 minutes in patients with urgency hypertensive crisis.
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