Why the study?
Does nifedipine improve hemodynamic parameters in patients with congestive heart failure?
Does nifedipine improve hemodynamic parameters in patients with congestive heart failure?
Sublingual nifedipine provides short-term hemodynamic improvement in congestive heart failure patients with low cardiac output and high systemic vascular resistance, but continuous administration may not sustain left ventricular function improvement at 24 hours.
Answers are grounded in this paper and cite their sources.
May warrant caution with continuous nifedipine in HF; leaves open sustained efficacy and optimal regimens.
Hemodynamic response of nifedipine in 11 patients with congestive heart failure was examined. Thirty minutes after sublingual administration of nifedipine, CI and SVI were increased together with a decrease in PAEDP and TSVRI. The increase in CI was proportional to the decrease in TSVRI. Twenty-four hours after continuous administration of nifedipine, however, six of 11 patients did not show the improvement of left ventricular function. These results indicate that sublingual administration of nifedipine is effective in the short-term therapy of the patients with a markedly decreased cardiac output and an increased systemic vascular resistance.
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MATSUI et al. (1979) studied this question.
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