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August 1, 1990AJP Renal Physiology

Exaggerated renal vascular reactivity to angiotensin and thromboxane in young genetically hypertensive rats

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Population

6-week-old anesthetized spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats

Comparison

Bolus injections of different doses of… vs Normotensive Wistar-Kyoto rats and…

Design

Preclinical

Authors

CCChristos ChatziantoniouInsermFDF. H. DanielsUniversity of North Carolina at Chapel HillWAWilliam J. ArendshorstUniversity of North Carolina at Chapel Hill

Discussion

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Overview

May inform renal mechanisms in genetic hypertension models; leaves open human translation.

Structured PICO

P
Population
6-week-old anesthetized spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats
I
Intervention
Bolus injections of different doses of angiotensin II and U46619 (stable receptor agonist of TxA2) into the renal artery before and during inhibition of prostaglandin synthesis by indomethacin
C
Comparator
Normotensive Wistar-Kyoto (WKY) rats and pre-injection/control conditions
O
Outcome
Renal blood flow (measured by electromagnetic flowmetry) and carotid arterial pressuresurrogate

Young spontaneously hypertensive rats exhibit exaggerated renal vascular reactivity to angiotensin II and thromboxane A2, which may contribute to the development of genetic hypertension.

Cite This Study

Chatziantoniou et al. (1990) studied this question.

synapsesocial.com/papers/6a7ec5e9e9bb045a73c2fe6dhttps://doi.org/10.1152/ajprenal.1990.259.2.f372
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin and thromboxane in genetically hypertensive rats: renal blood flow and receptor studies1991 · 48 citations
  2. 2Impaired ability of prostaglandins to buffer renal vasoconstriction in genetically hypertensive rats1992 · 36 citations
  3. 3Differential pressor and renal vascular reactivity to angiotensin II in spontaneously hypertensive and Wistar-Kyoto rats.1987 · 27 citations
  4. 4Enhanced renal angiotensin II subtype 1 receptor responses in the spontaneously hypertensive rat.1993 · 73 citations
  5. 5Proceedings of the Symposium ‘Angiotensin AT1 Receptors: From Molecular Physiology to Therapeutics’: STRUCTURAL CHANGES IN THE RENAL VASCULATURE IN THE SPONTANEOUSLY HYPERTENSIVE RAT: NO EFFECT OF ANGIOTENSIN II BLOCKADE1996 · 11 citations