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August 28, 2012Journal of Clinical HypertensionOpen Access

Mean sitting systolic/diastolic blood pressure reduced by -34.2/-20.3 mm Hg at week 28 and -37.3/-21.8 mm Hg at week 54, with corresponding blood pressure control rates of 69.1% and 77.1%.

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Why the study?

Does a triple combination of aliskiren, amlodipine, and hydrochlorothiazide improve blood pressure control in patients with moderate to severe hypertension?

Population

564 patients with moderate to severe hypertension

Design

Cohort, open-label

Follow-up

28 to 54 weeks

Authors

AMAlexander V. MurrayWKWolfgang KöenigJGJuan García‐Puig

Discussion

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Overview

Supports triple-combination evaluation in moderate-severe hypertension; leaves open comparative efficacy versus dual therapy in RCTs.

Structured PICO

Does a triple combination of aliskiren, amlodipine, and hydrochlorothiazide improve blood pressure control in patients with moderate to severe hypertension?

P
Population
564 patients with moderate to severe hypertension
I
Intervention
Aliskiren/hydrochlorothiazide (HCTZ) 300/12.5 mg for 1 week, followed by add-on amlodipine 5 mg for 1 week, after which doses of amlodipine and HCTZ were doubled, administered for 28 to 54 weeks
O
Outcome
Safety (adverse events) and efficacy (changes in blood pressure from baseline to endpoint and blood pressure control rate)surrogate

A triple combination of aliskiren, amlodipine, and hydrochlorothiazide provides significant blood pressure reductions and is well tolerated in patients with moderate to severe hypertension.

Cite This Study

Murray et al. (2012) studied this question.

synapsesocial.com/papers/6a7ee1356e4b721fcdc2fd60https://doi.org/10.1111/j.1751-7176.2012.00706.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinic and ambulatory blood pressure lowering effect of aliskiren/amlodipine/hydrochlorothiazide combination in patients with moderate-to-severe hypertension2012 · 20 citations
  2. 2Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension2009 · 66 citations
  3. 3Combination Therapy With Various Combinations of Aliskiren, Valsartan, and Hydrochlorothiazide in Hypertensive Patients Not Adequately Responsive to Hydrochlorothiazide Alone2009 · 41 citations
  4. 4A phase III, open-label, multicenter study to evaluate the safety and efficacy of long-term triple combination therapy with azilsartan, amlodipine, and hydrochlorothiazide in patients with essential hypertension2017 · 7 citations
  5. 5Treatment with aliskiren/amlodipine combination in patients with moderate-to-severe hypertension: a randomised, double-blind, active comparator trial2012 · 5 citations