This review summarizes the role, synthesis, and biologic effects of major cytokines and inflammatory factors in the pathophysiology of chronic heart failure.
Synthesizes cytokine pathways in chronic HF; leaves open targeted anti-inflammatory trials before any practice change.
Recent studies have emphasized the importance of biologically active molecules, termed cytokines, in the development and progression of the syndrome of chronic heart failure. This article summarizes a glossary of major cytokines and other cytokine-related inflammatory factors implicated in the pathophysiology of chronic heart failure, describing the source of their synthesis and factors regulating their secretion and analyzing their biologic effects on the cardiovascular system.
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Adamopoulos et al. (2001) studied this question.
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