Marked Reduction in Internal Atrial Defibrillation Thresholds With Dual-Current Pathways and Sequential Shocks in Humans
Why the study?
Does a dual-current pathway with sequential shocks reduce the atrial defibrillation threshold compared to a single-current pathway in patients with chronic atrial fibrillation?
Population
14 patients with chronic atrial fibrillation (duration 170+/-185 days)
Comparison
Dual-current pathway system using sequential… vs Single-current pathway using a single 7.5/2.5-ms…
Design
Other
Authors
Discussion
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Member takes
Implication
May support dual-pathway sequential shocks to lower atrial defibrillation thresholds; leaves open clinical adoption pending randomized trials.
Structured PICO
Does a dual-current pathway with sequential shocks reduce the atrial defibrillation threshold compared to a single-current pathway in patients with chronic atrial fibrillation?
P
Population
14 patients with chronic atrial fibrillation (duration 170+/-185 days)
I
Intervention
Dual-current pathway system (RA-->DCS followed by CSos-->LSV) using sequential 7.5/2.5-ms biphasic shocks with capacitor discharge waveforms for 150-microF and 600-microF capacitors
C
Comparator
Single-current pathway (RA-->DCS) using a single 7.5/2.5-ms biphasic shock from a 150-microF capacitor
O
Outcome
Atrial defibrillation threshold (ADFT)surrogate
Sequential biphasic waveforms delivered over dual-current pathways markedly reduce the atrial defibrillation threshold by >50% compared to a single shock over a single-current pathway.
Cite This Study
Cooper et al. (1998) studied this question.