October 21, 1997Circulation
Internal Cardioversion of Atrial Fibrillation
Why the study?
Do sequential biphasic shocks delivered through two current pathways reduce atrial defibrillation thresholds compared to standard single shocks in a sheep model of atrial fibrillation?
Population
12 adult sheep with sustained atrial fibrillation induced by rapid atrial pacing
Comparison
Sequential biphasic shocks delivered through two… vs Standard single shock delivered over a single…
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
May lower energy needs for atrial defibrillation devices; leaves open translation to human pain reduction and clinical use.
Structured PICO
Do sequential biphasic shocks delivered through two current pathways reduce atrial defibrillation thresholds compared to standard single shocks in a sheep model of atrial fibrillation?
P
Population
12 adult sheep with sustained atrial fibrillation induced by rapid atrial pacing
I
Intervention
Sequential biphasic shocks delivered through two current pathways (dual current pathway right atrial appendage to distal coronary sinus then proximal coronary sinus to pulmonary artery)
C
Comparator
Standard single shock delivered over a single current pathway (right atrial appendage to distal coronary sinus) or sequential shocks delivered over a single current pathway
O
Outcome
Defibrillation threshold (ED50 for delivered energy)surrogate
Sequential biphasic shocks delivered over two current pathways markedly reduce internal atrial defibrillation thresholds in a sheep model, which may help reduce pain associated with automatic atrial defibrillators.
Cite This Study
Cooper et al. (1997) studied this question.