Why the study?
The study aimed to investigate coagulation and platelet activation in blood collected from newly inserted catheters.
Does blood sampling immediately after catheter insertion without flush and discard increase coagulation activation compared to sampling after flush and discard in adult patients?
Does blood sampling immediately after catheter insertion without flush and discard increase coagulation activation compared to sampling after flush and discard in adult patients?
Blood drawn immediately from newly inserted central venous catheters exhibits marked coagulation activation, strongly supporting the clinical guideline to flush and discard an initial volume before sampling for haemostatic assays.
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Immediate CVC sampling associates with hypercoagulability; leaves open whether flush-and-discard improves hemostatic assay reliability.
Naddi et al. (2025) studied this question.
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