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January 1, 1983Nucleic Acids ResearchOpen Access

The nucleotide sequence of poliovirus type 3 leon 12 a1b: comparison with poliovirus type 1

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Population

Poliovirus type 3 (P3/Leon 12 a1 b) Sabin vaccine strain

Comparison

Nucleotide sequence analysis from cDNA cloned in… vs Poliovirus type 1

Design

Preclinical

Authors

GSGlyn StanwayUniversity of EssexACAlan J. CannInstitute of Cancer ResearchRHRudolf HauptmannBoehringer Ingelheim (Germany)

Discussion

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Implication

Provides basis for type 3 poliovirus attenuation analysis; extends homology data to type 1 but leaves open functional validation.

Structured PICO

P
Population
Poliovirus type 3 (P3/Leon 12 a1 b) Sabin vaccine strain
I
Intervention
Nucleotide sequence analysis from cDNA cloned in E. coli
C
Comparator
Poliovirus type 1
O
Outcome
Complete nucleotide sequence of the genome and homology comparison with type 1

The determination of the complete nucleotide sequence of the poliovirus type 3 Sabin vaccine strain provides a basis for understanding its attenuation and genetic stability compared to type 1.

Cite This Study

Stanway et al. (1983) studied this question.

synapsesocial.com/papers/6a7fa519feefc34aa44222bahttps://doi.org/10.1093/nar/11.16.5629
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Poliovirus type 3: molecular cloning of the genome and nucleotide sequence of the region encoding the protease and polymerase proteins1983 · 46 citations
  2. 2Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome.1982 · 310 citations
  3. 3Comparative biochemical studies of type 3 poliovirus1980 · 79 citations
  4. 4Characterization of Strains of Type 3 Poliovirus by Oligonucleotide Mapping1982 · 48 citations
  5. 5Cleavage sites within the poliovirus capsid protein precursors1982 · 63 citations