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August 13, 2026International Journal of Laboratory Hematology

Exceptional Clonal Activation of the RAS Signaling Pathway During MDS Progression

Mohammad Amir Guy Froyen Soepenberg Otto Brigitte Maes Sander De Bruyne

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Key Points

Examine the role and dynamics of clonal RAS signaling pathway activation during the progression of myelodysplastic syndromes.
Evaluation of molecular mechanisms and clonal dynamics underlying myelodysplastic syndrome evolution.
Assessment of RAS signaling pathway activation patterns during disease advancement.
Clonal expansion driven by RAS pathway activation is associated with disease progression in myelodysplastic syndromes.
Activation of RAS signaling serves as a critical molecular event during transformation to advanced disease stages.

Implication

Review highlights clonal activation of the RAS signaling pathway during MDS progression, indicating key drivers of leukemic transformation.

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Cite This Study

Amir et al. (2026) studied this question.

synapsesocial.com/papers/6a8019db75c2e31742c86137 https://doi.org/10.1111/ijlh.70221

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