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November 20, 2014The Journal of Sexual MedicineOpen Access

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

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Why the study?

Does diminazene aceturate improve hypercholesterolemia-induced corpus cavernosum injury in ApoE-/- mice?

Population

Hypercholesterolemic apolipoprotein E knockout mice, 15-20 weeks old, fed a Western-type diet. Age-matched…

Comparison

Diminazene aceturate 15 mg/kg per day… vs Vehicle (saline 0.9%) subcutaneously for 3 weeks.

Design

Preclinical, randomly assigned

Follow-up

3 weeks of treatment

Authors

FCFabiana P. Costa‐FragaÉcole Polytechnique Fédérale de LausanneFMFabrizio MontecuccoGeneral CardiologyMSM. SturnySwiss Polar Institute

Discussion

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Implication

ACE2 activation protects corpus cavernosum in hypercholesterolemic mice; leaves open translation to human erectile dysfunction therapy.

Structured PICO

Does diminazene aceturate improve hypercholesterolemia-induced corpus cavernosum injury in ApoE-/- mice?

P
Population
Hypercholesterolemic apolipoprotein E knockout (ApoE-/-) mice (n=40), 15-20 weeks old, fed a Western-type diet. Age-matched C57BL/6J wild type mice (n=20) on standard diet used as controls.
I
Intervention
Diminazene aceturate (DIZE) 15 mg/kg per day subcutaneously for 3 weeks.
C
Comparator
Vehicle (saline 0.9%) subcutaneously for 3 weeks.
O
Outcome
ACE2 expression and its role in modulating nitric oxide (NO)/ROS production and fibrosis within the corpus cavernosum.surrogate

Pharmacological activation of ACE2 with diminazene aceturate protects the corpus cavernosum against hypercholesterolemia-induced injury, suggesting a potential therapeutic target for erectile dysfunction.

Limitations

  • The levels of Ang II and Ang-(1-7) within the penis or ACE2 activity were not evaluated.

Cite This Study

Costa‐Fraga et al. (2014) studied this question.

synapsesocial.com/papers/6a80859604731064ad472cfbhttps://doi.org/10.1111/jsm.12757
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Angiotensin-Converting Enzyme 2/Angiogenesis-(1–7)/Mas Axis Confers Cardiopulmonary Protection against Lung Fibrosis and Pulmonary Hypertension2010 · 282 citations
  2. 2An Oral Formulation of Angiotensin-(1-7) Reverses Corpus Cavernosum Damages Induced by Hypercholesterolemia2013 · 43 citations
  3. 3Diminazene Aceturate Enhances Angiotensin-Converting Enzyme 2 Activity and Attenuates Ischemia-Induced Cardiac Pathophysiology2013 · 131 citations
  4. 4Angiotensin-Converting Enzyme 2 Activation Improves Endothelial Function2013 · 99 citations
  5. 5Telmisartan, ramipril and their combination improve endothelial function in different tissues in a murine model of cholesterol‐induced atherosclerosis2011 · 32 citations