. In parallel, drug-eluting stents offer site-specific therapeutic delivery to modulate local tissue responses, suppress fibrosis, and reduce infection risk. Although coronary stent technologies are extensively reviewed, an integrated analysis of biodegradable and drug-eluting stent innovations for non-vascular applications remains lacking. This review addresses this gap by systematically evaluating current and emerging stent technologies for major non-vascular luminal diseases. We examine the interplay between material properties, device mechanics, and the unique pathophysiological challenges of each anatomical site. We further highlight recent advances in biodegradable and drug-eluting stent design, discuss key barriers to clinical translation, and provide a forward-looking perspective on future directions in non-vascular stent development.
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