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December 1, 2000Cardiovascular Drug Reviews

ART‐123: Recombinant Human Soluble Thrombomodulin

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Population

Animal models of disseminated intravascular coagulation and AV-shunt, and patients with DIC or deep venous…

Comparison

ART-123 administered intravenously or… vs Conventional anticoagulants (in animal models)

Design

Review

Authors

MMMitsunobu MohriAsahi Kasei (Japan)

Discussion

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Implication

Supports evaluation of ART-123 in DIC; leaves open its role versus conventional anticoagulants pending randomized trials.

Structured PICO

P
Population
Animal models of disseminated intravascular coagulation (DIC) and AV-shunt, and patients with DIC or deep venous thrombosis (DVT)
I
Intervention
ART-123 (recombinant human soluble thrombomodulin) administered intravenously or subcutaneously
C
Comparator
Conventional anticoagulants (in animal models)
O
Outcome
Efficacy and safety in thrombotic diseases (DIC, DVT)

ART-123 is a promising anticoagulant that inhibits thrombin generation and promotes protein C activation, showing potential efficacy and safety in DIC and DVT.

Cite This Study

Mitsunobu Mohri (2000) studied this question.

synapsesocial.com/papers/6a80b0d12cf87dafd7c8b6a4https://doi.org/10.1111/j.1527-3466.2000.tb00055.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Recombinant Human Soluble Thrombomodulin (rhs-TM) on Clot-induced Coagulation in Human Plasma1998 · 23 citations
  2. 2Effects of Recombinant Human Soluble Thrombomodulin (rhs-TM) on a Rat Model of Disseminated Intravascular Coagulation with Decreased Levels of Plasma Antithrombin III1994 · 45 citations
  3. 3Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats1996 · 249 citations
  4. 4Recombinant thrombomodulin prevents endotoxin-induced lung injury in rats by inhibiting leukocyte activation1996 · 40 citations
  5. 5Inhibition of Thrombin-induced Neuronal Cell Death by Recombinant Thrombomodulin and E5510, a Synthetic Thrombin Receptor Signaling Inhibitor1999 · 32 citations