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April 4, 2011ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats

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Why the study?

Does exercise training improve the control of spontaneous diastolic Ca(2+) waves in failing cardiomyocytes from rats with post-myocardial infarction heart failure?

Population

Sprague-Dawley rats with post-myocardial infarction heart failure induced by coronary artery ligation

Comparison

Exercise training vs Sham-operated controls and untrained failing rats

Design

Preclinical

Authors

OKOle Johan KemiPreventive CardiologyNMNiall MacquaideGeorge Mason UniversityMHMorten A. HøydalNorwegian University of Science and Technology

Discussion

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Implication

Supports Ca²⁺ stabilization by exercise in rat post-MI HF models; leaves open human translation and clinical relevance.

Structured PICO

Does exercise training improve the control of spontaneous diastolic Ca(2+) waves in failing cardiomyocytes from rats with post-myocardial infarction heart failure?

P
Population
Sprague-Dawley rats with post-myocardial infarction heart failure induced by coronary artery ligation (left ventricular infarctions of 40 ± 5%)
I
Intervention
Exercise training
C
Comparator
Sham-operated controls and untrained failing rats
O
Outcome
Frequency of spontaneous diastolic Ca(2+) wavessurrogate

Exercise training improves cardiomyocyte control of diastolic Ca(2+) by reducing wave frequency and improving the ability to abort spontaneous waves in a rat model of post-MI heart failure.

Cite This Study

Kemi et al. (2011) studied this question.

synapsesocial.com/papers/6a815b1b6034bcd5e8690bcfhttps://doi.org/10.1002/jcp.22771

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endurance exercise training attenuates cardiac β2-adrenoceptor responsiveness and prevents ventricular fibrillation in animals susceptible to sudden death2005 · 36 citations
  2. 2Cellular Basis of Abnormal Calcium Transients of Failing Human Ventricular Myocytes2003 · 483 citations
  3. 3Interval Training Normalizes Cardiomyocyte Function, Diastolic Ca 2+ Control, and SR Ca 2+ Release Synchronicity in a Mouse Model of Diabetic Cardiomyopathy2009 · 203 citations
  4. 4The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts2010 · 59 citations
  5. 5Exercise training normalizes β-adrenoceptor expression in dogs susceptible to ventricular fibrillation2007 · 27 citations